Project description

In the origin of life, the transition from small building blocks to complex, organised assemblies set the stage for the emergence of biological systems. These supramolecular structures bridge the gap between simple organic molecules and the complex, organised systems that characterise living systems. By understanding these processes, we gain insights into the fundamental principles that govern the emergence of life on Earth. The PhD student will study the formation dynamics of supramolecular structures and how they adapt to signals from the environment, another hallmark of life. The studied supramolecular structures are stabilised by various non-covalent interactions and the self-assembly process in which they form remains poorly understood.

Using High speed-atomic force microscopy (High speed-AFM) the student will image, at the single-particle level, the formation dynamics of supramolecular structures. The ultimate goal is to elucidate in real time the dynamics and mechanisms behind formation and adaptive behaviour at the nanoscale. The adaptive behaviour will be probed by varying enverinmental conditions, in particular providing stimuli based on changes in ionic strength, pH, temperature and light flux. By studying surface based processes we directly asses templated assembly.

In this project, the formation dynamics and adaptive behaviour of various systems will be probed, starting with two distinct types of assemblies, nanopores and nanofibres/nanotubes. By further developing the High Speed-AFM approach to study these systems, the molecular basis of the adaptive behaviour of the assemblies will be scrutinized. The PhD student will work in close cooperation with the lab of Ben Feringa where the structures are synthesised.

Additional specifications

We look for a candidate with a MSc in Physics, Chemistry, Nanoscience or a related discipline. Experience with AFM is recommended, but not necessary