Project description

The cytoplasm of cells is a highly crowded environment and it is intriguing to see how biomolecular processes still can work in such an environment. Given that cells constantly convert energy, the cytoplasm has also been described as ‘active matter’. In this context, we recently proposed that metabolism could have an important role in ‘agitating the cytoplasm’ (https://doi.org/10.15252/msb.202110822). 

In this project, we aim to understand how cellular metabolism contributes to the organization of the cytoplasm, thus ‘marrying’ biochemistry and biophysics. To this end, we will use latest state-of-the-art tools, including super resolution microscopy, single-particle tracking, machine learning and mass photometry to investigate how active enzymes could get the cytoplasmic content in motion and therefore fulfill a crucial role in cellular functioning and life. Importantly, the successful candidate will be able to largely shape the course of project based on own prior expertise and interest, while still being able to draw on the work and techniques established in the host lab.

Additional specifications

We look for a candidate with a MSc in biophysics or biochemistry, with an interest to perform either microscopy experiments or to conduct in vitro biochemical experiments.